566) Which of the following statements is TRUE about local anesthetics?.
A. Local anesthetics do not cross the blood-brain barrier.
B. Local anesthetics agents contain a water-soluble benzene aromatic ring connected to a hydrophilic amine by an intermediate chain
C. Amides are degraded by hepatic carboxylesterase
D. Local anesthetics physiologic activity is a function of their water solubilityE. Amides are the most common group involved in allergic reactions.
REFERENCES & ANSWER
Liu S. S., Lin Yi: Local Anesthetics, Chapter 21 in Clinical Anesthesia, Barash, Paul G.; Cullen, Bruce F.; Stoelting, Robert K.; Cahalan, Michael K.; Stock, M. Christine, Lippincott Williams & Wilkins, 6th Edition, 2009, pp. 531-547
http://emedicine.medscape.com/article/873879-overview
566) C Amides are degraded by hepatic carboxylesterase
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